Oral Rehydration Solution: A “Low-Tech” Oft Neglected Therapy
Nutrition Issues in Gastroeneterology, Series #21, October 2004

Summary:  The concept of oral rehydration solutions arose from concerns in the public health
community regarding the high worldwide mortality occurring as a result of infectious diarrheas.
This was primarily in the Third World where death rates were as high as 5 million in the 1980’s.

This clinical setting and the discoveries related to the physiology of membrane structure and
function led to the most rapid successful clinical application of basic science principles that has
been experienced in modern medicine. Yet, this life-saving therapy has been slow to be accepted
by Western medicine. This review explores the underlying physiologic principle of oral rehydration
solution, discusses some of the critical literature in the field and provides some of the practical
application of oral rehydration in medical practice today.

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